ProstateCLR

Ingredients

Saw palmetto berries:  Saw palmetto berries are known to prevent the side effects caused by urinary tract problems mainly associated with Benign Prostatic Hyperplasia (BPH). Saw palmetto's health benefits rely on its ability to act as an anti-inflammatory agent. One study found that taking at least 160 mg of saw palmetto per day can improve the prostate symptom scores, along with the urinary flow rate and quality of life. (Reference: Ju, X.B., et al. (2015). [Efficacy and safety of Saw Palmetto Extract Capsules in the treatment of benign prostatic hyperplasia]. Ju, X.B., et al. Zhonghua Nan Ke Xue. 21(12):1098-101. Chinese. PMID: 26817302.)

Plant sterol complex (Beta-sitosterol): Beta-sitosterol has been shown in studies to improve urinary symptoms and flow measures. It may prevent frequent urination, improve prostate health and promote overall men's health. Additionally, beta-sitosterol may also reduce the risk of cardiovascular diseases due to its ability to lower cholesterol levels in the blood. (Reference:  Wilt, T., Alshani, A., MacDonald, R., Stark, G., Mulrow, C., and Lau, J. (2000). Cochrane Database Syst Rev. (2):CD001043. doi: 10.1002/14651858.CD001043. PMID: 10796740.)

Pygeum africanum bark: Pygeum contains several antioxidants that provide anti-inflammatory properties, particularly associated with the prostate. Several studies have shown that pygeum may improve the symptoms related to BPH, and it also enhances urinary flow measures. Pygeum is an herbal extract that is safe to take, and no side effects have been reported. (Reference: Wilt, T., Ishani, A., MacDonald R., and Stark, G. (2002). Pygeum africanum for benign prostatic hyperplasia. Cochrane Database Syst Rev. 2002;1998(1):CD001044. PMID: 11869585; PMCID: PMC7032619.)

Red raspberry: Red raspberries are mainly used to reduce the urgency to wake up frequently at night. They may support a complete emptying of the bladder. They have also been shown to improves urine flow while relieving pressure and discomfort and provide overall prostate health support. (Reference: Folmer, F., Basavaraju, U., Jaspars, M., Hold, G., El-Omar, E., Dicato, M., and diederich, M. (2014). Anticancer effects of bioactive berry compounds. Phytochemistry Reviews volume 13, pages295–322.)

Graviola leaf powder: Graviola is a natural ingredient that has been shown to support prostate health due to its ability to support the absorption of nutrients and essential vitamins vital for the functioning of the body. Graviola contains many antioxidants that help to protect the body against free radical damage. The antioxidant properties of this fantastic ingredient keep the prostate healthy by hunting free radicals, which can cause damage to nearby tissue or cells. (Reference: Deep, G. et al. (2016). Graviola inhibits hypoxia-induced NADPH oxidase activity in prostate cancer cells reducing their proliferation and clonogenicity. Sci. Rep. 6, 23135; doi: 10.1038/srep23135.)

Green tea leaf powder: Green tea is the most common beverage next to the water. It is a rich source of tea catechins, which are known to have antioxidant and anti-inflammatory properties. For centuries, green tea has been used in traditional medicine because of its health properties. It is crucial to notice that male populations in countries where large quantities of green tea are consumed regularly have the lowest incidence of chronic prostate conditions. (Reference: Pandey, M., and Gupta S. (2009). Green tea and prostate cancer: From bench to clinic. Frontiers in bioscience (Elite edition) 1(1):13-25.)

Cat's claw bark: Cat's claw bark provides many health benefits. For hundreds of years, the indigenous people of Peru used to take this herb because it offered many natural medicinal properties. Cat's claw bark is known to enhance the immune system and protect the body's organs due to its anti-inflammatory properties. It has also been shown to be effective against prostatitis and benign prostatic hyperplasia (BPH). (Reference: Navarro, M., Zamora, W., Quesada, S., Azofeifa, G., Alvarado, D., and Monagas, M. (2017). Fractioning of Proanthocyanidins of Uncaria tomentosa. Composition and Structure-Bioactivity Relationship. Antioxidants (Basel). 6(3): 60. doi: 10.3390/antiox6030060)

Broccoli: Broccoli is a cruciferous vegetable that is a rich source of natural plant chemicals known as glucoraphanins. These compounds have been shown in studies to interrupt pathways that cause inflammation and act as antioxidants to protect cells and DNA from damage caused by free radicals. With age, the prostate starts to suffer the adverse effects caused by inflammation, and these compounds are essential and essential to keep the prostate healthy and other organs. (Reference: Beaver, L., et al. (2017). Broccoli Sprouts Delay Prostate Cancer Formation and Decrease Prostate Cancer Severity with a Concurrent Decrease in HDAC3 Protein Expression in Transgenic Adenocarcinoma of the Mouse Prostate (TRAMP) Mice. Current Developments in Nutrition 2(3). DOI:10.1093/cdn/nzy002)

Tomato fruit powder: Tomatoes contain an essential compound known as lycopene. Men who consume canned or cooked tomatoes have a lower risk of getting prostate disorders. Tomatoes play a significant role in reducing a man's chance to develop a prostate disorder or chronic condition. Perhaps, the lycopene content has a lot to do with these health benefits. (Reference: Chen, P., et al. (2015). Lycopene and Risk of Prostate Cancer. Medicine (Baltimore). 94(33): e1260. doi: 10.1097/MD.0000000000001260.)

Stinging nettle leaf powder: Urtica dioica is commonly called stinging nettle. This plan is widely distributed throughout Europe, Asia, and North America. The leaves provide antioxidant, analgesic, antimicrobial properties. The stinging nettle extract is mainly studied because of its effectiveness in alleviating the symptoms of benign prostatic hyperplasia (BPH) and prostate health. (Reference: Levy, A., et al. (2014). Urtica dioica Induces Cytotoxicity in Human Prostate Carcinoma LNCaP Cells: Involvement of Oxidative Stress, Mitochondrial Depolarization and Apoptosis. Tropical Journal of Pharmaceutical Research. 13 (5): 711-717.)

Maitake mushroom powder: Maitake is a mushroom traditionally used in Asian countries like Japan and China. Mushrooms are rich in beta-glucans, which have been shown to enhance the immune system. Ingesting mushrooms have been shown to effectively prevent chronic prostate conditions and lessen the symptoms caused by prostate disorders. (Reference: Fullerton, S.A., Samadi, A.A., Totorelis, D.G., Choudhury, M.S., Mallouh, C., Tazaki, H., Kand Konno, S. (2000). Induction of apoptosis in human prostatic cancer cells with beta-glucan (Maitake mushroom polysaccharide). Mol Urol. 4(1):7-13.)

Reishi mushroom powder: Reishi mushrooms contain polysaccharides and other compounds responsible for their health effects. They can enhance the immune system by improving the number of white blood cells and lymphocytes.   In a research study, reishi mushrooms had the most vital action in inhibiting testosterone. The study concluded that reishi mushrooms significantly reduced levels of 5-alpha reductase, preventing the conversion of testosterone into the more potent DHT. High DHT levels are a risk factor for benign prostatic hyperplasia (BPH), acne, and baldness. (Reference: Grant, P., and Ramasamy, S. (2012). An Update on Plant-Derived Anti-Androgens. Int J Endocrinol Metab. Spring; 10(2): 497–502.)

Shiitake mushroom powder: Mushrooms can either be edible, medicinal, or poisonous. Many mushroom species, either edible or poisonous, contain bioactive compounds of significance to human health. Mushrooms contain beta-glucans that enhance the immune system through stimulating lymphocytes, NK cells, and macrophages, enhancing cytokine production, and more. Through this mechanism, Shiitake can prevent more chronic prostate conditions and promote overall Quality of Life. (Reference: deVere White, R.W., et al. (2002). Effects of a mushroom mycelium extract on the treatment of prostate cancer. Urology 60(4):640-4.)

Quercetin: Quercetin is a flavonoid with antioxidant properties obtained from colorful fruits and vegetables like apples, oranges, berries, leafy green vegetables, etc. As an antioxidant, it can prevent free radical damage, which can affect how the organs function. Some clinical trials have verified that quercetin may reduce the risk of chronic prostate disorders and is well-tolerated at high doses. (Reference: Yang, F., Song, L., Wang, H., and Wang, J. (2015). Quercetin in prostate cancer: Chemotherapeutic and chemopreventive effects, mechanisms and clinical application potential (Review). Oncology Reports. 33(6). DOI:10.3892/or.2015.3886.)

Juniper Berry powder: Juniper berry is usually used in teas, drinks, and supplements because of its ability to regulate urine flow and help clean the kidneys, bladder, and prostate from toxic chemicals and waste. Simultaneously, it has been used as an herbal remedy to reduce the symptoms caused by gout and gallstones. (Reference: Raasmaja, A., Stenius, U., and Ghalali, A. (2019) The Water Extract of Juniperus communis L. Induces Cell Death and Sensitizes Cancer Cells to Cytostatic Drugs through p53 and PI3K/Akt Pathways. Int J Mol Sci. 20(9): 2054. doi: 10.3390/ijms20092054.)

Uva Ursi leaf powder: Urva Ursi is used in teas, extracts, and even as tinctures to support urinary tract and bladder problems. It has also been used to protect the prostate against infections and inflammation. Urva Ursi may promote normal urination and prevent urinary tract infections by ridding the bladder of excess urine. (Reference: Yarnell, E. (2002). Botanical medicines for the urinary tract. World Journal of Urology. 20(5):285-93.)

Buchu leaf powder: Prostatitis is an inflammatory condition that affects the prostate. Buchu leaf powder and quercetin have been shown to provide several anti-inflammatory properties that are helpful to prevent inflammation on the prostate. Most of the time, the prostate gets inflamed due to a bacterial infection or perhaps other causes. (Reference: Skosana, B., et al. (2014). Buchu – The Multi-Purpose Ethnomedicinally Important Specie and Its Benefits in the Reproductive System. Antioxidant-Antidiabetic Agents and Human Health. Chapter 13. DOI:10.5772/57233.)

L-glycine, L-alanine, and l-glutamic acid: Several studies have shown that a diet rich in amino acids like glutamic acid, alanine, and glycine is essential to improve the symptoms of prostate disorders. These amino acids have been shown in several studies to relieve the symptoms of an enlarged prostate. As an example, patients taking these amino acids experienced reduced nighttime urination, reduced urgency, reduced frequency, and alleviation of delayed urination. (Reference: Zaman, C., Lin, K., and O'Neill, W. (2005). The Therapeutic Effect of Amino Acids in Prostate Cancer Patients. Journal of Complementary and Integrative Medicine: Vol. 2: No. 1, Article 12)

Calcium: Calcium is vital to the prostate and overall health. Not getting enough calcium can increase the risk of osteoporosis, even among men. Further, some treatments can increase the risk of bone loss and fractures for men with prostate cancer, so trying to avoid calcium entirely is not a good idea. (Reference: Baron, J.A., Beach, M., Wallace, K., Grau, M.V., Sandler, R.S., Mandel, J.S., Heber, D., and Greenberg, E... (2005). Risk of prostate cancer in a randomized clinical trial of calcium supplementation. Cancer Epidemiol Biomarkers Prev. 14(3):586-9.)

Pumpkin seed powder: Pumpkin seeds are also known as pepitas. They are the edible seeds of a pumpkin. Whether you enjoy them raw or in the form of pumpkin seed oil, they are packed with nutrition and may aid prostate health. Pumpkin seeds are a popular folk remedy for men's health concerns. (Reference: Hong, H., Kim, C.S., and Maeng, S. (2009). Effects of pumpkin seed oil and saw palmetto oil in Korean men with symptomatic benign prostatic hyperplasia. Winter. 3(4): 323–327.)

Burdock root powder: Burdock root powder contains antioxidants such as phenolic acids, quercetin, and luteolin. These antioxidants are known to protect the body from oxidative stress caused by free radical damage. Burdock root also contains arctiin, a polyphenol known to provide support to the prostate. (Reference: Matsuzaki, Y., et al. (2008). Arctiin induces cell growth inhibition through the down-regulation of cyclin D1 expression. Oncol Rep. 19(3):721-7.)

Cayenne pepper fruit powder: The ingredient that makes the pepper hot, capsaicin, is thought to provide support to prevent chronic prostate health conditions. Capsaicin has been known to improve circulation, appetite, and digestion along with providing essential anti-inflammatory properties. (Reference: Ramos-Torres, A., Bort, A., Morell, C., Rodriguez-Henche, N., and Diaz-Laviada, I. (2016). The pepper's natural ingredient capsaicin induces autophagy blockage in prostate cancer cells. Oncotarget. 7(2): 1569–1583.)

Goldenseal root powder: Goldenseal root powder contains an alkaloid known as berberine. Several studies have shown to inhibit the spread of chronic prostate conditions. Goldenseal has also been used as a natural herbal remedy to reduce the symptoms caused by prostatitis and urinary tract infections. (Reference: Liu, C.H., et al. (2015). Berberine inhibits the metastatic ability of prostate cancer cells by suppressing epithelial-to-mesenchymal transition (EMT)-associated genes with predictive and prognostic relevance. Int J Med Sci.12(1):63-71. doi: 10.7150/ijms.9982. eCollection 2015.)

Gravel root powder: Although gravel root powder is often used to support kidney, gout, and arthritis, several studies have also helped provide prostate support. The gravel root powder is also beneficial in reducing the symptoms caused by the prostate, urethra, bladder, and other urinary tract infections. (Reference: Hensel, A., et al. (2011). Eupatorium perfoliatum L.: Phytochemistry, traditional use, and current applications. Journal of Ethnopharmacology. 138(3):641-51.

Marshmallow root powder: Marshmallow root powder provides anti-inflammatory properties that decrease painful urination and promote better prostate health. These symptoms are usually present when the person has prostatitis or other inflammatory conditions of the prostate. (Reference: Al-Snafi, A., et al. (2013). The Pharmaceutical importance of Althaea officinalis and Althaea rosea: A review. International Journal of PharmTech Research. 5(3):1378-1385.)

Parsley leaf powder: Petroselinum crispum (parsley) is a common herb of the Apiaceae family cultivated throughout the world and is mainly used as a seasoning condiment. Studies have shown that parsley provides important health properties as a natural herb to support the prostate. Parsley extracts also provide essential antioxidant properties, protection against DNA damage, and the inhibition of several prostate conditions. (Reference: Camiel, L.D., and Song, K.Y. (2002). Herbs for Benign Prostatic Hyperplasia. Annals of Pharmacotherapy. 36(9):1443-52. Tang, E.L.H., and et al. (2015). Petroselinum crispum has antioxidant properties, protects against DNA damage and inhibits proliferation and migration of cancer cells. J Sci Food Agric. 95(13):2763-71. doi: 10.1002/jsfa.7078.)

Vitamin E: Vitamin E is a fat-soluble antioxidant that supports free radicals' neutralization and prevents oxidative damage to DNA, proteins, lipids, etc. Vitamin E may protect against chronic diseases that may affect the prostate and others, such as heart and blood vessel conditions. (Reference: Rizvi, S., Raza, S. T., Ahmed, F., Ahmad, A., Abbas, S., and Mahdi, F. (2014). The Role of Vitamin E in Human Health and Some Diseases. Sultan Qaboos Univ Med J. 14(2): e157–e165.)

Vitamin B6: Vitamin B6 is involved in over 100 different physiological processes, including cellular respiration, amino acid metabolism, and prostate support. It can be obtained from beans, grains, meat, poultry, fish, and some fruits or vegetables. Studies have shown that it may provide anti-inflammatory and antioxidant properties associated with the urinary tract, the bladder, and the prostate. (Reference: Mocellin, S., Briarava, M., and Pilati, P. (2017). Vitamin B6 and Cancer Risk: A Field Synopsis and Meta-Analysis. JNCI: Journal of the National Cancer Institute, Volume 109, Issue 3, djw230, https://doi.org/10.1093/jnci/djw230)

Zinc: Zinc is a mineral that plays an essential role in cell growth and DNA repair. At the same time, zinc is mainly found in prostate tissues because it plays a vital role in the development and normal functioning of the prostate. When the prostate is functioning at normal levels, zinc is present in high levels. (Reference: Gómez, Y., Arocha, F., Espinoza, F., Fernández, D., Vásquez, A., Granadillo, V. (2007). Zinc levels in prostatic fluid of patients with prostate pathologies. Invest Clin. 48:287–94.)

Selenium: Selenium is mainly obtained from grains, meat, poultry, fish, eggs, and dairy products. Several epidemiologic studies suggest that selenium is a prospective mineral to prevent chronic disorders in the prostate. It has been known that having healthy selenium levels reduce the incidence of getting prostate disorders. (Reference: Platz, E.A., and Helzlsouer, K.J. (2001). Selenium, zinc, and prostate cancer. Epidemiol Rev. 23(1):93-101. doi: 10.1093/oxfordjournals.epirev.a000801. PMID: 11588860.)

Copper: Copper is an essential trace mineral involved in metabolism. It is also an antioxidant that is needed for the activation of DNA and RNA. Recent studies have focused on copper's ability to prevent chronic prostate disorders because copper is often stored when conditions worsen. (Reference: Safi, R., et al. (2014). Copper Signaling Axis as a Target for Prostate Cancer Therapeutics. Cancer Res. (74) (20) 5819-5831; DOI: 10.1158/0008-5472.CAN-13-3527.)